5-ETHENYL-L-PROLINE METHYL ESTER HYDROCHLORIDE synthesis

3synthesis methods

Product Name:5-ETHENYL-L-PROLINE METHYL ESTER HYDROCHLORIDE
CAS Number:328974-80-7
Molecular formula:C8H13NO2
Molecular Weight:155.19

(2S)-5-Allyl-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester

195964-65-9
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5-ETHENYL-L-PROLINE METHYL ESTER HYDROCHLORIDE

328974-80-7
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 1.) O₃; 2.) NaBH₄ / 1.) MeOH, CH₂Cl₂, -78 deg C; 2.) MeOH, CH₂Cl₂, -78 deg C to RT
2: (n-Bu)3P / tetrahydrofuran
3: 1.) MCPBA; 2.) Me₂S, Et₃N / 1.) CH₂Cl₂, -70 deg C, 30 min; 2.) CH₂Cl₂, -70 deg C to RT
4: TFA / CH₂Cl₂

References:

Beal, Laura M.;Moeller, Kevin D. [Tetrahedron Letters,1998,vol. 39,# 26,p. 4639 - 4642]

1,2-Pyrrolidinedicarboxylic acid, 5-ethenyl-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,5S)-

328974-72-7
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328974-80-7
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References

1,2-Pyrrolidinedicarboxylic acid, 5-(2-hydroxyethyl)-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S)-

210345-05-4
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328974-80-7
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References