ChemicalBook CAS DataBase List 5-ethynylfuran-2-carbaldehyde

5-ethynylfuran-2-carbaldehyde synthesis

2synthesis methods

Product Name:5-ethynylfuran-2-carbaldehyde
CAS Number:153026-71-2
Molecular formula:C7H4O2
Molecular Weight:120.11

5-[2-(trimethylsilyl)ethynyl]furan-2-carbaldehyde

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Yield:153026-71-2 98%

Reaction Conditions:

with potassium carbonate in methanol; for 2 h;

Steps:

5j.2 Preparation of 5-ethynylfuran-2-carbaldehyde:

5-((trimethylsilyl)ethynyl)furan-2-carbaldehyde (15.52 g, 80.7 mmol) was dissolved in methanol (300 mL). K₂CO₃ (33.46 g, 242.1 mmol) was added. The mixture was reacted under stirring for 2 hours, and rotary-evaporated to dryness. Ethyl acetate (300 mL) and water (300 mL) were added. The mixture was extracted. The organic phase was dried over anhydrous sodium sulphate, and rotary-evaporated to dryness to give a yellow solid (9.5 g) in a yield of 98%.

References:

EP3750881,2020,A1 Location in patent:Paragraph 0195; 0198-0199

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References