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5-Ethynylisophthalic acid synthesis
- Product Name:5-Ethynylisophthalic acid
- CAS Number:432025-97-3
- Molecular formula:C10H6O4
- Molecular Weight:190.15
![1,3-Benzenedicarboxylic acid, 5-[2-(triMethylsilyl)ethynyl]-, 1,3-diMethyl ester](/CAS/20150408/GIF/313648-72-5.gif)
313648-72-5
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![5-Ethynylisophthalic acid](/CAS/20180703/GIF/432025-97-3.gif)
432025-97-3
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$43.00/100mg
Yield: 77%
Reaction Conditions:
Stage #1:dimethyl 5-(trimethylsilylethynyl)benzene-1,3-dicarboxylate with sodium hydroxide in tetrahydrofuran at 20; for 4 h;
Stage #2: with water;sodium hydroxide at 20; for 2 h;
Steps:
2
5-Ethynylisophthalic acid (4). 5-Ethynylisophthalic acid was prepared in one step by reacting dimethyl-5-(trimethylsilylethynyl)isophthaloate (3) (0.7 g, 3.2 mmol) with NaOH (1.412 g, 35.3 mmol) in THF (20 ml) at r. t. for 4 h. The precipitate formed was centrifuged down, dissolved in aq. NaOH (0.1 M, 50 ml) and stirred for 2 h at room temperature. The reaction mixture was cooled to 0° C. on an ice bath, acidified with 10% HCl to pH1-2. The precipitate formed was isolated by centrifugation, washed twice with water and dried, giving the target compound as a powder. Yield: 0.47 g, 77%.
References:
VINOGRADOV, Sergei A.;Esipova, Tatiana V. US2014/4048, 2014, A1 Location in patent:Paragraph 0089
![DiMethyl 5-ethynylisophthalate](/CAS/20150408/GIF/313648-56-5.gif)
313648-56-5
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$68.40/250mg
![5-Ethynylisophthalic acid](/CAS/20180703/GIF/432025-97-3.gif)
432025-97-3
57 suppliers
$43.00/100mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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432025-97-3
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$43.00/100mg
![DIMETHYL 5-IODOISOPHTHALATE](/CAS/GIF/51839-15-7.gif)
51839-15-7
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$6.00/250mg
![5-Ethynylisophthalic acid](/CAS/20180703/GIF/432025-97-3.gif)
432025-97-3
57 suppliers
$43.00/100mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
![5-Ethynylisophthalic acid](/CAS/20180703/GIF/432025-97-3.gif)
432025-97-3
57 suppliers
$43.00/100mg