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5-fluoro-1H-indole-7-carboxylic acid synthesis

3synthesis methods
-

Yield:875305-87-6 54%

Reaction Conditions:

Stage #1: 7-bromo-5-fluoro-1H-indolewith sec.-butyllithium in tetrahydrofuran;cyclohexane at -75;
Stage #2: carbon dioxide in tetrahydrofuran;cyclohexane;cooling;

References:

Schlosser, Manfred;Ginanneschi, Assunta;Leroux, Frederic [European Journal of Organic Chemistry,2006,# 13,p. 2956 - 2969]