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741693-89-0

5-Fluoro-2-Methoxy-1-naphthalenol synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: NaNO2; HBF4
1.2: decahydronaphthalene / 160 °C
2.1: base
3.1: SnCl4 / CH2Cl2 / 0 °C
4.1: m-CPBA
5.1: NaOH

References:

Kuo;Gillespie;Kulanthaivel;Lantz;Ma;Nelson;Threlkeld;Wheeler;Yi;Zmijewski [Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,# 13,p. 3481 - 3486]