5-Fluoro-2-nitro benzylbromide synthesis
- Product Name:5-Fluoro-2-nitro benzylbromide
- CAS Number:82420-35-7
- Molecular formula:C7H5BrFNO2
- Molecular Weight:234.02
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Yield: 93%
Reaction Conditions:
with carbon tetrabromide;triphenylphosphine in dichloromethane for 3 h;
Steps:
81 Example 81; 2-(Bromomethyl)-4-fluoro-1-nitrobenzene
To a solution of (5-Fluoro-2-nitrophenyl) methanol (0.3 g, 1.75 mmol) in methylene chloride (5 mL0 was added triphenylphosphine (0.52 g, 2.01 mmol) and carbon tetrabromide (0.66 g, 2.01 mmol). After 3 hours, the reaction was concentrated and chromatographed using 3:1 hexane:ethyl acetate as eluant to provide 0.38 g (93%) of the desired product as white crystals. mp 38-41°C. Anal Calc'd for C7H5N3O2FBr: C, 35.93; H, 2.15; N, 5.99. Found: C, 35.97; H, 2.12; N, 5.91.
References:
Wyeth Holdings Corporation EP1147095, 2004, B1 Location in patent:Page 91
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