5-Fluoro-2-nitrophenylacetic acid synthesis
- Product Name:5-Fluoro-2-nitrophenylacetic acid
- CAS Number:29640-98-0
- Molecular formula:C8H6FNO4
- Molecular Weight:199.14
1875-89-4
173 suppliers
$20.00/1g
29640-98-0
110 suppliers
$11.00/250mg
Yield:29640-98-0 87%
Reaction Conditions:
with ammonium nitrate;trifluoroacetic anhydride in chloroform at 0; for 3 h;
Steps:
15 Preparation 15; (5-FLUORO-2-NITRO-PHENYL)-ACETIC ACID
3-methyl phenethyl alcohol (5 g, 36.7 MMOL) was diluted in 30 mL of chloroform and ammonium nitrate (3.12 g, 38.9 MMOL) was added. The reaction mixture was cooled to 0 °C and trifluor acetic acid anhydride (16.02 mL, 113 MMOL) was added dropwise. The reaction stirred at 0 °C for 3 hours before water was added to slowly quench the reaction. The chloroform layer was washed with water then collected and dried over NA2SO4 then concentrated. The desired isomer crystallized out of the crude solution in ethyl acetate and was then triturated with acetonitrile to afford 5.25 g of the desired isomer as a brown solid. Yield 87%; MS (APCI) : 199 [M-H]-.
References:
WARNER-LAMBERT COMPANY LLC WO2004/41793, 2004, A1 Location in patent:Page 58
331-25-9
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$6.23/5g
29640-98-0
110 suppliers
$11.00/250mg
29640-99-1
35 suppliers
$253.75/1g
29640-98-0
110 suppliers
$11.00/250mg
64123-77-9
84 suppliers
$6.00/1g
29640-98-0
110 suppliers
$11.00/250mg