5-Fluoro-6-methyl-benzothiazol-2-ylamine synthesis
- Product Name:5-Fluoro-6-methyl-benzothiazol-2-ylamine
- CAS Number:1155287-47-0
- Molecular formula:C8H7FN2S
- Molecular Weight:182.22
452-77-7
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Yield:1155287-47-0 99%
Reaction Conditions:
with acetic acid at 20; for 3 h;
Steps:
118 5-Fluoro-6-methylbenzojdjthiazol-2-amine
3-Fluoro-4-methylaniline (5.0 g, 40 mmol) and KSCN (15.5 g, 160 mmol) in AcOH (50 mL) was cooled to 0 °C and Br2 (6.7 g, 42 mmol) in AcOH (20 mL) was added slowly. The mixture was then stirred at rt for 3 h. The reaction mixture was quenched with ice-cold NH4OH (100 mL). The resulting solid was filtered, washed with water, and dried under vacuum to give the title compound (6.0 g, 99%)as a yellow solid. MS (ES+) C8H7FN2S requires: 182, found: 183 [M+Hf’.
References:
WO2018/81276,2018,A1 Location in patent:Page/Page column 149