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ChemicalBook CAS DataBase List 5-FLUORO-DL-TRYPTOPHAN

5-FLUORO-DL-TRYPTOPHAN synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1: water; acetic acid / 3 h / 0 °C / Inert atmosphere
2: tetrahydrofuran / 1 h / 0 - 20 °C
3: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere
4: hydrogenchloride / tetrahydrofuran / 1 h / 20 °C
5: potassium hydroxide / methanol; water

References:

Füller, Janis J.;Röpke, René;Krausze, Joern;Rennhack, Kim E.;Daniel, Nils P.;Blankenfeldt, Wulf;Schulz, Stefan;Jahn, Dieter;Moser, Jürgen [Journal of Biological Chemistry,2016,vol. 291,# 38,p. 20068 - 20084]

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