5-Fluoro-indole-6-carboxylic acid Methyl ester synthesis

5synthesis methods

Product Name:5-Fluoro-indole-6-carboxylic acid Methyl ester
CAS Number:1227268-61-2
Molecular formula:C10H8FNO2
Molecular Weight:193.17

Benzoic acid, 4-[(1E)-2-(dimethylamino)ethenyl]-2-fluoro-5-nitro-, methyl ester

1609967-04-5
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5-Fluoro-indole-6-carboxylic acid Methyl ester

1227268-61-2
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Yield:1227268-61-2 90%

Reaction Conditions:

with 5%-palladium/activated carbon;hydrogen in ethyl acetate; for 2 h;

Steps:

13-4 Preparation Example 13-4: synthesis of 5-fluoro-1H-indole-6-carboxylic acid methyl ester

The compound (2.0g, 7.5mmol) obtained from Preparation Example 13-3 was dissolved in ethyl acetate (100ml). 5% Palladium/carbon (100mg) was added, and the mixture was stirred for 2 hours under hydrogen gas. After completion of the reaction, the mixture was filtered with Celite, distilled under reduced pressure and separated by column chromatography to obtain the title compound (1.3g, 90%). [602] NMR:¹H-NMR(400HMz, CDCl₃); δ 8.68 (br s, 1H), 8.04 (d, 1H), 7.40 (dd, 1H), 7.34 (d, 1H), 6.54 (dd, 1H), 3.95 (s, 3H)

References:

WO2014/73904,2014,A1 Location in patent:Paragraph 599-602

753924-40-2 Synthesis