5-Formamide-1-(2-formyloxyethl)pyrazole synthesis
- Product Name:5-Formamide-1-(2-formyloxyethl)pyrazole
- CAS Number:116856-18-9
- Molecular formula:C7H9N3O3
- Molecular Weight:183.16
73616-27-0
139 suppliers
$8.00/1g
116856-18-9
133 suppliers
$5.00/1g
Yield:-
Reaction Conditions:
with formic acid;acetic anhydride in tetrahydrofuran;water;ethyl acetate
Steps:
1 Preparation 1
Preparation 1 A mixture of acetic anhydride (11.13 ml) and formic acid (5.93 ml) was stirred at room temperature for 30 minutes. To this solution was added 5-amino-1-(2-hydroxyethyl)pyrazole (5 g) under ice-cooling, and the mixture was stirred at 30°-40° C. for 1 hour. The reaction mixture was poured into a mixture of water, tetrahydrofuran and ethyl acetate and adjusted to pH 6 with aqueous sodium bicarbonate. The organic layer was separated, and the aqueous layer was extracted with a mixture of tetrahydrofuran and ethyl acetate for three times. The organic layers were combined, dried over magnesium sulfate and evaporated in vacuo to give 5-formamido-1-(2-formyloxyethyl)pyrazole (5.18 g). IR (Nujol): 3180, 1705, 1660 cm-1 NMR (DMSO-d6, δ): 4.21-4.61 (4H, m), 6.11 and 6.34 (1H, each d, J=3Hz), 7.47 (1H, d, J=3Hz), 8.00 (1H, s), 8.33 (1H, s)
References:
Fujisawa Pharmaceutical Co., Ltd. US5187160, 1993, A
64-18-6
1060 suppliers
$22.12/250ML
73616-27-0
139 suppliers
$8.00/1g
116856-18-9
133 suppliers
$5.00/1g