5-Formyl-2-methoxy-benzonitrile synthesis

12synthesis methods

Product Name:5-Formyl-2-methoxy-benzonitrile
CAS Number:21962-50-5
Molecular formula:C9H7NO2
Molecular Weight:161.16

Benzonitrile, 5-(hydroxymethyl)-2-methoxy- (9CI)

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21962-50-5
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Yield:21962-50-5 100%

Reaction Conditions:

with Dess-Martin periodane in dichloromethane at 20; for 2 h;

Steps:

8.4 Step 4: Preparation of 5-formyl-2-methoxyphenyl cyanide

In a solution of compound a '(845 mg, 5.2 mol) in dichloromethane (50 mL)(1,1,1-triacetyl) -1,1-dihydro-1,2-benzoyl-3 (1-hydro) -one (2.6 g, 6.2 mmol) was added.And the mixture was stirred at room temperature for 2 hours. The resulting reaction was dried and concentrated, and the resulting residue was subjected to flash column chromatography (petroleum ether: ethyl acetate = 3: 1) to give the white solid compound b ': 5-formyl-2-methoxybenzonitrile (845 mg, Yield 100%).

References:

CN106146504,2016,A Location in patent:Paragraph 0219; 0220; 0221; 0228; 0229