5-Hexenoic acid, 2,2-dimethyl-, methyl ester synthesis
1synthesis methods
- Product Name:5-Hexenoic acid, 2,2-dimethyl-, methyl ester
- CAS Number:252206-21-6
- Molecular formula:C9H16O2
- Molecular Weight:156.22
Yield:252206-21-6 76%
Reaction Conditions:
Stage #1: Methyl isobutyratewith lithium diisopropyl amide in tetrahydrofuran;hexane; for 0.333333 h;
Stage #2: 1-bromo-4-butene in tetrahydrofuran;N,N,N,N,N,N-hexamethylphosphoric triamide;hexane at -78; for 12 h;
References:
Liu, Cong;Wang, Xiang;Pei, Tao;Widenhoefer, Ross A. [Chemistry - A European Journal,2004,vol. 10,# 24,p. 6343 - 6352]