5-Hydroxy-2-phenyl-1-benzofuran-3-carboxylic acid synthesis
- Product Name:5-Hydroxy-2-phenyl-1-benzofuran-3-carboxylic acid
- CAS Number:75161-15-8
- Molecular formula:C15H10O4
- Molecular Weight:254.24
4610-75-7
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$50.00/25mg
75161-15-8
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$497.31/5MG
Yield:-
Reaction Conditions:
with lithium hydroxide monohydrate in 1,4-dioxane at 20;Inert atmosphere;
Steps:
19.1
19.1 Synthesis5-hydroxyl-2-phenylbenzofuran3-carboxylate(hereinafter referred to as compound 19-1),Will 120mg of compound 19-1,24.2mg LiOH·H2O addedUp to 8 mL of 1,4-dioxane, nitrogen-protected overnight at room temperature,Hydrochloric acid adjusts pH to neutral,Extracted with ethyl acetate (50 mL×3).Saturated NaCl wash,Dry anhydrous Na2SO4,Concentrated under reduced pressure,Adding dichloromethane to precipitate the precipitate,Filter white solid5-hydroxyl-2-phenylbenzofuran-3-carboxylic acid(Compound 19-2).
References:
CN109942523,2019,A Location in patent:Paragraph 0133; 0134
94-02-0
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75161-15-8
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106-51-4
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75161-15-8
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98-86-2
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$9.00/5g
75161-15-8
12 suppliers
$497.31/5MG