ChemicalBook CAS DataBase List 5-hydroxybenzo[b]thiophene-2-carboxylic acid

5-hydroxybenzo[b]thiophene-2-carboxylic acid synthesis

7synthesis methods

Product Name:5-hydroxybenzo[b]thiophene-2-carboxylic acid
CAS Number:95094-87-4
Molecular formula:C9H6O3S
Molecular Weight:194.21

2-Propenoic acid, 3-(3-hydroxyphenyl)-2-mercapto-

42056-20-2
0 suppliers
inquiry

5-hydroxybenzo[b]thiophene-2-carboxylic acid

95094-87-4
12 suppliers
inquiry

Yield:95094-87-4 35%

Reaction Conditions:

with iodine in tetrahydrofuran; for 26 h;Reflux;

Steps:

83 Synthesis of Compound 4

A stirred solution of compound 3 (38.6 g, 195.94 mmol) and iodine (62.5 g, 244.92 mmol) in dry THF was heated to reflux for 26 h. After removing almost of THF, the residue was poured into water. The pH was adjusted to 12 by progressively adding solid NaOH and the water phase was washed with EA for 3 times, then the water phase was acidified by conc.HCl to pH 2. The result precipitate was collected by filtration, washed by water, dried to give compound 4 (13.5 g, 35%) as light yellow solid.

References:

JP2015/214548,2015,A Location in patent:Paragraph 1384; 1388; 1389

20699-85-8 Synthesis