5-(HydroxyMethyl)-2-Methylisonicotinaldehyde synthesis

1synthesis methods

Product Name:5-(HydroxyMethyl)-2-Methylisonicotinaldehyde
CAS Number:17210-37-6
Molecular formula:C8H9NO2
Molecular Weight:151.16

diMethyl 6-Methylpyridine-3,4-dicarboxylate

56912-90-4
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5-(HydroxyMethyl)-2-Methylisonicotinaldehyde

17210-37-6
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate; (Mn,Ti)O₂ / ethanol / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 4 h / 20 °C / pH 3.5
2.1: hydroxylamine hydrochloride; sodium acetate monohydrate / water

References:

Abbas, Sk Jahir;Ramacharyulu;Ke, Shyue-Chu [RSC Advances,2016,vol. 6,# 13,p. 10242 - 10248]