5-Iodobenzofuran-2-carboxylic acid synthesis

Yield:1144854-04-5 66%

Reaction Conditions:

Stage #1: 5-iodobenzofuran-2-carboxylic acid ethyl esterwith potassium hydroxide in ethanol;water; for 1 h;Reflux;
Stage #2: with hydrogenchloride in water; pH=2 - 3;Heating;

References:

Newman, Amy Hauck;Grundt, Peter;Cyriac, George;Deschamps, Jeffrey R.;Taylor, Michelle;Kumar, Rakesh;Ho, David;Luedtke, Robert R. [Journal of Medicinal Chemistry,2009,vol. 52,# 8,p. 2559 - 2570] Location in patent:experimental part