5-iodoisophthalic acid synthesis
- Product Name:5-iodoisophthalic acid
- CAS Number:51839-16-8
- Molecular formula:C8H5IO4
- Molecular Weight:292.03
51839-15-7
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Yield:51839-16-8 455 mg
Reaction Conditions:
with water;sodium hydroxide in methanol at 40; for 18 h;Inert atmosphere;
Steps:
5-Iodoisophthalic acid (18).
To a solution of dimethyl 5-iodoisophthalate (500 mg, 1.56 mmol, 1.0 eq) inMeOH (20 mL) was added an aqueous 1 M NaOH solution (4.69 mL, 4.69 mmol,3.0 eq). After stirring at 40 °C temperature for 18 h, the brown suspension was diluted with water (10mL) and acidified to pH 3 with aqueous 1M HCl solution. The aqueous layer was extracted withEtOAc (3 x 20 mL). Combined organic extracts were washed with brine (20 mL), dried overanhydrous Na2SO4 and evaporated under reduced pressure to yield product 18 as a yellowish solid(455 mg, 100% yield), which was used in subsequent step without purification. 1H-NMR spectrumwas identical to that from the literature.9
References:
Zogota, Rimants;Kinena, Linda;Withers-Martinez, Chrislaine;Blackman, Michael J.;Bobrovs, Raitis;Pantelejevs, Teodors;Kanepe-Lapsa, Iveta;Ozola, Vita;Jaudzems, Kristaps;Suna, Edgars;Jirgensons, Aigars [European Journal of Medicinal Chemistry,2019,vol. 163,p. 344 - 352] Location in patent:supporting information
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99-27-4
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