5-ISOPROPYL-THIOPHENE-3-CARBOXYLIC ACID synthesis
- Product Name:5-ISOPROPYL-THIOPHENE-3-CARBOXYLIC ACID
- CAS Number:123418-51-9
- Molecular formula:C8H10O2S
- Molecular Weight:170.23
166591-47-5
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123418-51-9
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Yield:123418-51-9 680 mg (81%)
Reaction Conditions:
with potassium hydroxide;silver nitrate in ethanol;
Steps:
34.b 34b.
34b. 2-Isopropyl-4-thiophene carboxylic acid A solution of AgNO3 (1.01 g, 5.92 mmol)in 10 mL of H20 and 15 mL of a solution of KOH (1.63 g, 40.8 mmol) were sequentially added to a solution of 760 mg (4.9 mmol) of 2-isopropyl-4-thiophene carboxaldehyde, from step 34a above, in 25 mL of ethanol. The resulting black mixture was stirred at room temperature for 2 hours and filtered. The filtrate was washed with ether, then acidified with 6N HCl and extracted with ether. The extract was washed with H2 O and brine, dried over MgSO4 and concentrated to give 680 mg (81%) of the title compound as a yellow solid. mp. 64°-67° C.
References:
US5597832,1997,A
123418-50-8
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123418-51-9
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65416-85-5
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123418-51-9
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590-86-3
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123418-51-9
17 suppliers
$45.00/50mg