![](/CAS/GIF/19254-84-3.gif)
5-METHOXY-1 3-BENZENEDIMETHANOL 97 synthesis
- Product Name:5-METHOXY-1 3-BENZENEDIMETHANOL 97
- CAS Number:19254-84-3
- Molecular formula:C9H12O3
- Molecular Weight:168.19
![DIMETHYL 5-METHOXYISOPHTHALATE](/CAS/GIF/20319-44-2.gif)
20319-44-2
61 suppliers
$45.00/50mg
![5-METHOXY-1 3-BENZENEDIMETHANOL 97](/CAS/GIF/19254-84-3.gif)
19254-84-3
19 suppliers
$122.00/1g
Yield:19254-84-3 90%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 20;Reflux;
Steps:
3,5-Bis(hydroxymethyl)anisole.
To a mixture of LiAlH4 (306 mg, 8.05 mmol) in anhydrous THF (20 mL) was added drop wise a solution of 5-methoxy-isophthalic acid dimethyl ester (600 mg, 2.68 mmol) in THF (20 mL). The resulting mixture was refluxed for 2 h and then stirred at room temperature overnight. The reaction was quenched subsequently by adding ethyl acetate (1.0 mL), ethanol (1.0 mL) and water (1 mL). The reaction mixture was filtered and the filtrate was evaporated under reduced pressures to give 3,5-bis(hydroxymethyl) anisole (405 mg, 90%). 1H NMR (CDCl3, 400 MHz) δ 6.84 (s, 1H) 6.74 (s, 2H) 4.53 (s, 4H) 3.75 (s, 3H) 3.14 (br, 2H) and ESI-MS: m/z 191.36 ([M+Na]+). The 1H NMR data are in agreement with the ones reported in literatures. 5
References:
Yu, Xi-Hui;Peng, Chen-Chen;Sun, Xiao-Xiao;Chen, Wen-Hua [European Journal of Medicinal Chemistry,2018,vol. 152,p. 115 - 125] Location in patent:supporting information
![5-METHOXYISOPHTHALIC ACID](/CAS/GIF/46331-50-4.gif)
46331-50-4
121 suppliers
$11.00/250mg
![5-METHOXY-1 3-BENZENEDIMETHANOL 97](/CAS/GIF/19254-84-3.gif)
19254-84-3
19 suppliers
$122.00/1g
![5-Hydroxyisophthalic acid](/CAS/GIF/618-83-7.gif)
618-83-7
295 suppliers
$9.00/10g
![5-METHOXY-1 3-BENZENEDIMETHANOL 97](/CAS/GIF/19254-84-3.gif)
19254-84-3
19 suppliers
$122.00/1g
![Dimethyl 5-hydroxyisophthalate](/CAS/GIF/13036-02-7.gif)
13036-02-7
177 suppliers
$6.00/5g
![5-METHOXY-1 3-BENZENEDIMETHANOL 97](/CAS/GIF/19254-84-3.gif)
19254-84-3
19 suppliers
$122.00/1g
![DIMETHYL 5-METHOXYISOPHTHALATE](/CAS/GIF/20319-44-2.gif)
20319-44-2
61 suppliers
$45.00/50mg
![Benzoic acid, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-methoxy-, methyl ester](/CAS/20210305/GIF/1126431-84-2.gif)
1126431-84-2
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![5-METHOXY-1 3-BENZENEDIMETHANOL 97](/CAS/GIF/19254-84-3.gif)
19254-84-3
19 suppliers
$122.00/1g