5-Methoxy-2-methyl-benzofuran-3-carboxylic acid synthesis

6synthesis methods

Product Name:5-Methoxy-2-methyl-benzofuran-3-carboxylic acid
CAS Number:29735-88-4
Molecular formula:C11H10O4
Molecular Weight:206.19

ethyl 5-methoxy-2-methylbenzofuran-3-carboxylate

7287-51-6
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5-Methoxy-2-methyl-benzofuran-3-carboxylic acid

29735-88-4
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Yield:29735-88-4 97%

Reaction Conditions:

with water;potassium hydroxide in ethanol at 80; for 12 h;

Steps:

1.3; 2.3; 3.3; 4.3; 5.3

3) Dissolve the resulting ethyl 5-methoxy-2-methylbenzofuran-3-carboxylate (4) (13.0g) in 100 mL ethanol,Add 4.2 g of potassium hydroxide in 100 mL of aqueous solution, and react under reflux at 80 °C. for 12 h. After the TLC tracking reaction is over, the ethanol is removed by rotary evaporation. 0.9 mL of hydrochloric acid solution was added, and the pH value of the resulting solution was adjusted to 3. At this time, a large amount of yellow solid was precipitated. After suction filtration, the solid was washed three times with 100 mL of water. The solid was dissolved in 200 mL of ethyl acetate, separated to remove the remaining aqueous layer, and dried by adding anhydrous sodium sulfate. After suction filtration, the solvent was removed by rotary evaporation, and finally a pale yellow solid was obtained, which was 5-methoxy-2-methylbenzofuran-3-carboxylic acid (5), and the yield was 97%. The resulting product has not been characterized and is directly put into the next reaction

References:

CN113698375,2021,A Location in patent:Paragraph 0105-0107; 0112; 0119; 0123; 0127; 0131; 0135; ...

106-51-4 Synthesis