ChemicalBook CAS DataBase List 5-METHOXY-2-NITROBENZONITRILE

5-METHOXY-2-NITROBENZONITRILE synthesis

5synthesis methods

Product Name:5-METHOXY-2-NITROBENZONITRILE
CAS Number:38469-84-0
Molecular formula:C8H6N2O3
Molecular Weight:178.14

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Yield:38469-84-0 92%

Reaction Conditions:

with triethylamine;trifluoroacetic anhydride in dichloromethane at 20; for 1 h;

Steps:

101.2

A 100 mL round bottom flask was charged with 5-methoxy-2- nitrobenzamide (2.1 g, 0.01 mol), trifluoroacetic anhydride (2.2 mL), triethylamine (2.9 mL) and CH₂C1₂ (30 mL). The resulting solution was stirred at room temperature for 1 h. Work-up: the reaction solution was washed with H₂0 (30 mL x 2). The organic layer was dried over anhydrous Na₂S0₄ and concentrated in vacuo, to give 1.75 g (92%) of the product as white solid. MS m/z: 179 (M+H⁺).

References:

WO2011/112731,2011,A2 Location in patent:Page/Page column 143

41994-92-7 Synthesis