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5-Methoxy-3-phenylbenzoic acid synthesis

3synthesis methods
-

Yield:1214369-81-9 95.6%

Reaction Conditions:

with lithium hydroxide monohydrate in tetrahydrofuran;water at 0 - 20; for 16 h;

References:

Magee, Thomas V.;Brown, Matthew F.;Starr, Jeremy T.;Ackley, David C.;Abramite, Joseph A.;Aubrecht, Jiri;Butler, Andrew;Crandon, Jared L.;Dib-Hajj, Fadia;Flanagan, Mark E.;Granskog, Karl;Hardink, Joel R.;Huband, Michael D.;Irvine, Rebecca;Kuhn, Michael;Leach, Karen L.;Li, Bryan;Lin, Jian;Luke, David R.;Macvane, Shawn H.;Miller, Alita A.;McCurdy, Sandra;McKim, James M.;Nicolau, David P.;Nguyen, Thuy-Trinh;Noe, Mark C.;O'Donnell, John P.;Seibel, Scott B.;Shen, Yue;Stepan, Antonia F.;Tomaras, Andrew P.;Wilga, Paul C.;Zhang, Li;Xu, Jinfeng;Chen, Jinshan Michael [Journal of Medicinal Chemistry,2013,vol. 56,# 12,p. 5079 - 5093]