5-(Methoxycarbonyl)-1H-indole-2-carboxylicacid synthesis
- Product Name:5-(Methoxycarbonyl)-1H-indole-2-carboxylicacid
- CAS Number:681288-76-6
- Molecular formula:C11H9NO4
- Molecular Weight:219.19
796871-00-6
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681288-76-6
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Yield:681288-76-6 91%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon at 25; under 750.075 Torr; for 1 h;
Steps:
Benzyl 5-methoxycarbonylindole-2-carboxylate (9.8 mg, 0.032 mmol) and 10% Pd/C (2.5 mg) in 640 μL THF were stirred under H2 (1 bar) for 1 h at 25° C., then filtered over Celite. The catalyst was washed with THF (1 mL) and the filtrate was evaporated to afford 5-methoxycarbonyl-indole-2-carboxylic acid 192 (6.3 mg, 91%) as an off-white solid: mp 281° C. (dec.); ESI (positive) m/z 220 (M+H+, C11H10NO4); ESI (negative) m/z 218 (M-H-, C11H8NO4).
References:
US2005/26987,2005,A1 Location in patent:Page 28
19718-49-1
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127-17-3
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681288-76-6
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$124.00/1g
619-45-4
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681288-76-6
32 suppliers
$124.00/1g