ChemicalBook CAS DataBase List 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE

5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE synthesis

5synthesis methods

Product Name:5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
CAS Number:98700-50-6
Molecular formula:C11H10N2O
Molecular Weight:186.21

(5-METHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL

153863-35-5
51 suppliers
$29.00/1g

5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE

98700-50-6
40 suppliers
$87.00/250mg

Yield:98700-50-6 95%

Reaction Conditions:

with 4-methylmorpholine N-oxide;tetrapropylammonium perruthennate in dichloromethane; for 0.666667 h;Molecular sieve;

Steps:

5

Tetrapropylammonium perruthenate (76 mg) was added to a mixture of (5-methyl-1- phenyl-1 H-pyrazol-4~yl)methanol (816 mg, 4.3 mmol), 4-methylmorpholine N-oxide (754 mg, 6.45 mmol) and molecular sieves (4 A) in dry dichloromethane (12.6 ml). The reaction was stirred for 40 minutes then filtered through a silica plug washing with dichloromethane. Concentration yielded 5-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde as a pale yellow solid (763 mg, 95 %).LCMS (A) Rt = 2.39 minutes; m/z [M+H]⁺ = 187

References:

WO2006/67462,2006,A1 Location in patent:Page/Page column 47

59-88-1 Synthesis