5-Methyl-4-nitroindole synthesis
- Product Name:5-Methyl-4-nitroindole
- CAS Number:61149-54-0
- Molecular formula:C9H8N2O2
- Molecular Weight:176.17
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Yield:-
Reaction Conditions:
Stage #1: 4-nitro-1H-indoIe;methylmagnesium chloridewith N,N,N,N,N,N-hexamethylphosphoric triamide in tetrahydrofuran at -30; for 0.25 h;
Stage #2: with lead(IV) acetate;acetic acid in tetrahydrofuran;dichloromethane at -30 - 20;Title compound not separated from byproducts;
References:
Lu, Haige;He, Kaizhang;Kool, Eric T. [Angewandte Chemie - International Edition,2004,vol. 43,# 43,p. 5834 - 5836]