5-(methylamino)pentanoic acid synthesis

5synthesis methods

Product Name:5-(methylamino)pentanoic acid
CAS Number:21382-30-9
Molecular formula:C6H13NO2
Molecular Weight:131.17

931-20-4
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Yield:21382-30-9 98%

Reaction Conditions:

with hydrogenchloride at 80; for 40 h;Reflux;

Steps:

12. 5-(Methylamino)pentanoic acid (15)

A mixture of 1-methylpiperidin-2-one (14, 3.0 g, 26.5 mmol) and 10 ml of 6 Nhydrochloric acid was heated for 16 h to 80 oC. Subsequently 5 ml ofconcentrated hydrochloric acid were added and the reaction mixture was heatedfor 24 h to reflux. The mixture was cooled to room temperature andconcentrated under reduced pressure. The remainder was taken up in diethylether and the resulting suspension was stirred for 1 h, then filtered. The solidwas collected and dried in high vacuum to deliver 5-(methylamino)pentanoicacid hydrochloride salt (15, 4.4 g, 26.1 mmol, 98 %),

References:

Sulzer-Mosse, Sarah;Lamberth, Clemens;Kubizna, Peter [Synlett,2017,vol. 28,# 17,art. no. ST-2017-B0164-L,p. 2277 - 2280]

675-20-7 Synthesis