5-nitro-1,2,3,4-tetrahydroquinoline synthesis

4synthesis methods

Product Name:5-nitro-1,2,3,4-tetrahydroquinoline
CAS Number:39217-91-9
Molecular formula:C9H10N2O2
Molecular Weight:178.19

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Yield:39217-91-9 82%

Reaction Conditions:

with iodine;4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane in dichloromethane at 20; for 24 h;

Steps:

5 The specific synthetic steps of 5-nitro-tetrahydroquinoline are as follows

Elemental iodine (0.05 mmol) and 5-nitro-quinoline (0.25 mmol) were added to the reaction flask to displace the air.Dichloromethane (1 mL) and pinacol borane (1 mmol) were added separately;After stirring at room temperature for 24 hours,The reaction mixture was diluted with methylene chloride (5 mL).Concentrated to a crude product,The crude product was separated by column chromatography (ethyl acetate: petroleum ether 1% to 10%).5-nitro-tetrahydroquinoline, yellow solid,The yield was 82%.

References:

CN108822030,2018,A Location in patent:Paragraph 0027; 0028; 0029; 0030

635-46-1 Synthesis