5-NITRO-PYRIDINE-2-SULFONYL CHLORIDE synthesis
- Product Name:5-NITRO-PYRIDINE-2-SULFONYL CHLORIDE
- CAS Number:174485-82-6
- Molecular formula:C5H3ClN2O4S
- Molecular Weight:222.61
2127-09-5
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Yield: 47%
Reaction Conditions:
with hydrogenchloride;water;chlorine;acetic acidCooling;
Steps:
1.E131
To an ice-cold solution of 5-nitro-pyridine-2-thiol (1.27 g, 8.13 mmol) in 1N aqueous HCl (25 mL) and acetic acid (5 mL) was vigorously bubbled chlorine (gas) for 15 min, followed by nitrogen for 5 min. the solid was collected by filtration, washed with cold 1N aqueous HCl and water and dried in vacuo: yield 842 mg (47%). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 9.60 (d, J=2.0 Hz, 1H), 8.84 (dd, J=8.6, 2.3 Hz, 1H), 8.35 (d, J=8.6 Hz, 1H).
References:
Anacor Pharmaceuticals, Inc.;GlaxoSmithKline US2010/256092, 2010, A1 Location in patent:Page/Page column 137
2127-10-8
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$55.00/500 mg
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