ChemicalBook CAS DataBase List 5-NITROQUINOXALINE

5-NITROQUINOXALINE synthesis

5synthesis methods

Product Name:5-NITROQUINOXALINE
CAS Number:18514-76-6
Molecular formula:C8H5N3O2
Molecular Weight:175.14

131543-46-9 Synthesis

131543-46-9
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3694-52-8 Synthesis

3694-52-8
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18514-76-6
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Yield:18514-76-6 97%

Reaction Conditions:

in ethanol at 85; for 2 h;

Steps:

108 General Procedure 108: 5-Nitroquinoxaline (Intermediate 481)

General Procedure 108: 5-Nitroquinoxaline (Intermediate 481)Oxaldehyde (40% in water; 1.43 ml, 31.3 mmol) was added to a solution of 3-nitro-o-phenylene-diamine (600 mg, 3.9 mmol) in EtOH (15 ml) and the mixture was heated at 85° C. for 2 h. The solvent was removed in vacuo, the residue was diluted in water and the aqueous phase was extracted with DCM. The organic phase was dried (Na2SO4) and concentrated in vacuo. The crude residue was purified by column chromatography with DCM/MeOH (99:1) as the eluent to give the title compound (666 mg, 97%).MW: 175.15HPLCMS: (Method C): [m/z]: 176

References:

US2012/214803,2012,A1 Location in patent:Page/Page column 174