5-oxa-nonanedioic acid synthesis
- Product Name:5-oxa-nonanedioic acid
- CAS Number:7423-25-8
- Molecular formula:C8H14O5
- Molecular Weight:190.19
3403-82-5
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Yield:7423-25-8 90.5%
Reaction Conditions:
with Jones reagent in acetone at 20; for 0.5 h;
Steps:
3 Step 3:
500 ml four-necked bottleCompound 2 (10.0 g, 55.7 mmol),Acetone (210 mL),Turn on stirring,Add Jones reagent (62 mL, 165.5 mmol),The reaction was carried out at room temperature for 30 minutes.The reaction solution was poured into 0.5 M sodium hydroxide solution to quench (600 mL),Extract with ethyl acetate (150 mL x 2) and discard the organic phase.The aqueous phase was adjusted to pH 1-2 with 1 M hydrochloric acid, extracted with ethyl acetate (150 mL × 2), and the organic phase was washed with saturated brine (100 mL × 2), dried over anhydrous sodium sulfate, filtered, and the filtrate was filtered. dry,The target compound 3 (9.6 g, 50.4 mmol, 90.5%) was obtained in high purity.
References:
CN110642682,2020,A Location in patent:Paragraph 0005; 0011
176720-03-9
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7423-25-8
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96-48-0
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629-36-7
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854831-05-3
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