5-(OXETAN-3-YL)BENZO[D][1,3]DIOXOLE synthesis
- Product Name:5-(OXETAN-3-YL)BENZO[D][1,3]DIOXOLE
- CAS Number:1044507-54-1
- Molecular formula:C10H10O3
- Molecular Weight:178.18
26272-85-5
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94839-07-3
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1044507-54-1
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Yield:1044507-54-1 69%
Reaction Conditions:
Stage #1: 3,4-(methylenedioxy)-benzeneboronic acidwith nickel(II) iodide;trans-2-aminocyclohexanol hydrochloride;sodium hexamethyldisilazane in isopropyl alcohol;Inert atmosphere;
Stage #2: 3-iodooxetane in isopropyl alcohol at 80; for 0.333333 h;Microwave irradiation;Suzuki coupling;
References:
Duncton, Matthew A. J.;Estiarte, M. Angels;Tan, Darlene;Kaub, Carl;O'Mahony, Donogh J. R.;Johnson, Russell J.;Cox, Matthew;Edwards, William T.;Wan, Min;Kincaid, John;Kelly, Michael G. [Organic Letters,2008,vol. 10,# 15,p. 3259 - 3262] Location in patent:experimental part