5-OXO-5-(3-TRIFLUOROMETHYLPHENYL)VALERIC ACID synthesis
- Product Name:5-OXO-5-(3-TRIFLUOROMETHYLPHENYL)VALERIC ACID
- CAS Number:502650-98-8
- Molecular formula:C12H11F3O3
- Molecular Weight:260.21
108-55-4
432 suppliers
$6.00/25g
401-78-5
397 suppliers
$5.00/5g
502650-98-8
12 suppliers
$366.00/1g
Yield:502650-98-8 27%
Reaction Conditions:
Stage #1: 1-bromo-3-(trifluoromethyl)benzenewith iodine;magnesium in tetrahydrofuran at 35; for 1.25 h;Inert atmosphere;Grignard Reaction;
Stage #2: dihydro-2H-pyran-2,6(3H)-dione in tetrahydrofuran at 0 - 20;Inert atmosphere;
References:
Awalt, Jon Kyle;Nguyen, Anh T.N.;Fyfe, Tim J.;Thai, Bui San;White, Paul J.;Christopoulos, Arthur;J?rg, Manuela;May, Lauren T.;Scammells, Peter J. [Journal of Medicinal Chemistry,2022,vol. 65,# 13,p. 9076 - 9095]