![](/CAS/20180703/GIF/1421951-81-6.gif)
5-(Pentafluoroethyl)pyridine-2-carbonitrile synthesis
- Product Name:5-(Pentafluoroethyl)pyridine-2-carbonitrile
- CAS Number:1421951-81-6
- Molecular formula:C8H3F5N2
- Molecular Weight:222.11
![ZINC CYANIDE](/CAS/GIF/557-21-1.gif)
557-21-1
86 suppliers
$12.00/5g
![2-Chloro-5-(pentafluoroethyl)pyridine](/CAS/20180703/GIF/118559-21-0.gif)
118559-21-0
11 suppliers
$90.50/100mg
![5-(Pentafluoroethyl)pyridine-2-carbonitrile](/CAS/20180703/GIF/1421951-81-6.gif)
1421951-81-6
9 suppliers
$109.00/100mg
Yield:1421951-81-6 4.19 g
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0) in 1-methyl-pyrrolidin-2-one at 80; for 2.5 h;
Steps:
47.2 Production Example 47(2)
Production Example 47(2) A mixture of the half amount of 2-chloro-5- pentafluoroethyl pyridine obtained in Production Example 47(1), zinc (II) cyanide (14.4 g) , tetrakistriphenylphosphine palladium (2.42 g) and N-methyl pyrrolidone (84 ml) was heated to 80°C, and stirred for 2.5 hours. The reaction mixture was cooled to room temperature, and water and methyl-tert-butyl ether were poured thereto. The resulting precipitate was filtrated through celite (registered trademark) , and the residue was washed with methyl-tert-butyl ether. The filtrate was extracted with methyl-tert-butyl ether. The organic layer was dried over sodium sulfate, and concentrated under reduced pressure. The crude product was subjected to silica gel column chromatography to give 2-cyano-5-pentafluoroethyl pyridine .(4.19 g) . 2-cyano-5-pentafluoroethyl pyridine 1H-NMR (CDC13) δ : 8.97-8.96 (lH,m), 8.12-8.09 (lH,m), 7.90- 7.87 (lH,m)
References:
WO2013/18928,2013,A1 Location in patent:Paragraph 0389
![Zinc cyanide (Zn(NC)) (9CI)](/CAS/20211123/GIF/748101-41-9.gif)
748101-41-9
0 suppliers
inquiry
![2-Chloro-5-(pentafluoroethyl)pyridine](/CAS/20180703/GIF/118559-21-0.gif)
118559-21-0
11 suppliers
$90.50/100mg
![5-(Pentafluoroethyl)pyridine-2-carbonitrile](/CAS/20180703/GIF/1421951-81-6.gif)
1421951-81-6
9 suppliers
$109.00/100mg
![2-Chloro-5-iodopyridine](/CAS/GIF/69045-79-0.gif)
69045-79-0
350 suppliers
$5.00/1g
![5-(Pentafluoroethyl)pyridine-2-carbonitrile](/CAS/20180703/GIF/1421951-81-6.gif)
1421951-81-6
9 suppliers
$109.00/100mg