5-PHENETHYL-[1,3,4]THIADIAZOL-2-YLAMINE synthesis
- Product Name:5-PHENETHYL-[1,3,4]THIADIAZOL-2-YLAMINE
- CAS Number:39181-40-3
- Molecular formula:C10H11N3S
- Molecular Weight:205.28
79-19-6
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$14.00/1g
501-52-0
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$14.14/1gm:
39181-40-3
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$60.00/100mg
Yield:39181-40-3 89%
Reaction Conditions:
Stage #1: thiosemicarbazide;3-Phenylpropionic acidwith trichlorophosphate at 75; for 0.5 h;
Stage #2: with water for 4 h;Reflux;
Steps:
5.1.1. 5-Phenyl-1,3,4-thiadiazol-2-amino (2a)
General procedure: A stirring mixture of benzoic acid (6.10 g, 50 mmol), N-aminothiourea (4.55 g, 50 mmol) and POCl3 (13 ml) was heated at 75 °C for 0.5 h. After cooling down to room temperature, water (55 ml) was added. The reaction mixture was refluxed for 4 h. After cooling, the mixture was basified to pH 8 by the dropwise addition of 50% NaOH solution under stirring. The precipitate was filtered and recrystallized from ethanol to yield 8.14 g of the target compound 2a as a colorless crystal. Yield: 92%
References:
Guan, Peng;Sun, Feng'E;Hou, Xuben;Wang, Feng;Yi, Fan;Xu, Wenfang;Fang, Hao [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 12,p. 3865 - 3872] Location in patent:experimental part
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333-20-0
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39181-40-3
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$60.00/100mg
104-53-0
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39181-40-3
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$60.00/100mg