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5-PHENYL-2-METHYL-4-THIAZOLE-CARBOXYLIC ACID synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: potassium tert-butylate / tetrahydrofuran / -60 - 20 °C
2.1: acetonitrile / 5 h / Molecular sieve
2.2: 6 h / 50 °C
3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h
3.2: pH 3 - 4 / Cooling with ice

References:

Aissaoui, Hamed;Boss, Christoph;Gude, Markus;Koberstein, Ralf;Sifferlen, Thierry US2011/263662, 2011, A1

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