5-Phenylnaphthalene-1-carboxylic acid synthesis
- Product Name:5-Phenylnaphthalene-1-carboxylic acid
- CAS Number:179473-63-3
- Molecular formula:C17H12O2
- Molecular Weight:248.28
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Yield:179473-63-3 70%
Reaction Conditions:
with sodium phosphate dodecahydrate;5%-palladium/activated carbon in isopropyl alcohol at 20; for 12 h;Inert atmosphere;
Steps:
3.II
II. Add to the 100mL reaction bottleIntermediate 1 (714 mg, 2.86 mmol),Phenylboronic acid (419 mg, 3.4 mmol),Sodium phosphate dodecahydrate (3.8 g, 10 mmol)Dissolved in 50% isopropanol solution (100 mL),Add 5‰Pd/C (0.003g),Nitrogen protection,The reaction was carried out for 12 h with stirring at room temperature.After the reaction is completed,Take out the reaction solution,Acidified to pH ≤ 2 with 10% dilute hydrochloric acid,Extracted with ethyl acetate as the organic phase,The organic layer was then dried over anhydrous sodium sulfate.Concentrated and dried to obtain intermediate product 5,The yield was 70%.
References:
CN108314630,2018,A Location in patent:Paragraph 0084; 0086
16726-67-3
100 suppliers
$15.00/250mg
179473-63-3
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86-55-5
366 suppliers
$5.00/5g
179473-63-3
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