(5-PhenylpyriMidin-2-yl)MethanaMine synthesis
- Product Name:(5-PhenylpyriMidin-2-yl)MethanaMine
- CAS Number:944903-70-2
- Molecular formula:C11H11N3
- Molecular Weight:185.23
85386-18-1
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Yield:-
Reaction Conditions:
with 10% Pd/C;hydrogen in methanol at 20;
Steps:
Step B: (5-phenylpyrimidin-2-yl)methanamine
e of 5-phenylpyrimidine-2-carbonitrile (16 g.0.086 mol) and palladium on carbon (10%, 1.50 g) was sparged with nitrogen. Methanol (300 mL) was added, and the mixture was purged with hydrogen gas. The reaction mixture was stirred at room temperature under a hydrogen atmosphere for 4 hours. The reaction mixture was filtered through Celite (washing with methanol). The filtrate was concentrated under reduced pressure to afford (5-phenylpyrimidin-2- yl)methanamine, which was used without purification in the next step.1H NMR (400 MHz, chloroform-d) δ 9.90 (s, 2H), 7.58-7.45 (m, 5H), 4.17 (s, 2H).
References:
WO2022/232333,2022,A1 Location in patent:Page/Page column 189
98-80-6
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