5-Propyl-2H-tetrazole synthesis

Yield:14389-13-0 98%

Reaction Conditions:

with sodium azide;1,1'-disulfo-[2,2'-bipyridine]-1,1'-diium chloride in ethylene glycol at 80; for 1.5 h;Green chemistry;

Steps:

2.3. General procedure for the synthesis of 5-substituted 1H-tetrazoles

General procedure: A mixture of nitriles (1 mmol), NaN3 (1.5 mmol), [BiPy](HSO₃)₂Cl₂ as catalyst (4 mol %) in EG (3 mL) as green solvent was heated at 80 °C for 1-2 h. the reaction was monitored using TLC. After completion of the reaction, the reaction mixture was cooled to room temperature. Then H₂O (5 mL) was added (the catalyst was separated from the reaction mixture with solving in water), and extraction with ethyl acetate was performed. The corresponding tetrazole was extracted with ethyl acetate (2 ×15 ml). The resultant organic layer was washed with distilled water, dried over anhydrous sodium sulfate and concentrated by distillation to afford the crude solid product. The crude material was purified enough but for more purification, column chromatography on silica gel (hexane/AcOEt 1:1) was afforded.

References:

Aali, Elaheh;Gholizadeh, Mostafa;Noroozi-Shad, Nazanin [Journal of Molecular Structure,2022,vol. 1247,art. no. 131289]