ChemicalBook CAS DataBase List 5-Pyridin-4-ylthiophene-2-carboxaldehyde 97%

5-Pyridin-4-ylthiophene-2-carboxaldehyde 97% synthesis

6synthesis methods

Product Name:5-Pyridin-4-ylthiophene-2-carboxaldehyde 97%
CAS Number:129770-69-0
Molecular formula:C10H7NOS
Molecular Weight:189.23

4701-17-1 Synthesis

4701-17-1
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1692-15-5 Synthesis

1692-15-5
444 suppliers
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5-Pyridin-4-ylthiophene-2-carboxaldehyde 97%

129770-69-0
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$45.00/10mg

Yield:129770-69-0 85%

Reaction Conditions:

with palladium diacetate;sodium carbonate;triphenylphosphine in 1,4-dioxane;water;Inert atmosphere;Reflux;

Steps:

13.5 Example 13-5
Synthesis of Intermediate 13-5: 5-(pyridin-4-yl)thiophene-2-carbaldehyde

Under the protection of nitrogen atmosphere, 5-bromo-2-thiophenecarboxaldehyde (3.80 g, 20.0 mmol), pyridine-4-boronic acid (3.0 g, 24.0 mmol), Na₂CO₃ (3.18 g, 30.0 mmol), Pd(OAc)₂ (224.0 mg, 1.0 mmol) and PPh₃ (520.0 mg, 2.0 mmol) were dissolved in the mixed solvent of dioxane and water (v/v=3:1, 80 mL), then refluxed and reacted overnight.
After the reaction was completed, the reaction mixture was cooled to RT, poured into ice-water and extracted with EA.
The combined organic phase was washed with water, dried with Na₂SO₄.
The crude product was separated by column chromatography to give the desired product (3.2 g, yield 85.0%).

References:

US2020/190066,2020,A1 Location in patent:Paragraph 0270-0271

4701-17-1 Synthesis

4701-17-1
298 suppliers
$6.00/1g

181219-01-2 Synthesis