5-(pyrimidin-5-yl)isophthalic acid synthesis

Yield:1417570-15-0 93.7%

Reaction Conditions:

Stage #1: 5-(pyrimidin-5-yl) isophthalic acid diethyl esterwith potassium hydroxide in methanol at 80; for 24 h;
Stage #2: with hydrogenchloride in water; pH=Ca. 2 - 3; for 24 h;

References:

Du, Liting;Lu, Zhiyong;Zheng, Kaiyuan;Wang, Junyi;Zheng, Xin;Pan, Yi;You, Xiaozeng;Bai, Junfeng [Journal of the American Chemical Society,2013,vol. 135,# 2,p. 562 - 565] Location in patent:supporting information