5-PYRROLIDIN-1-YL-1,3,4-THIADIAZOL-2-AMINE synthesis

Yield:71125-45-6 10 mg

Reaction Conditions:

with potassium carbonate in 1,4-dioxane at 100; for 0.5 h;Microwave irradiation;

Steps:

0173-1 0173-1>

Example 0173
0173-1>
A solution of 5-bromo-1,3,4-thiadiazole-2-amine (20 mg), potassium carbonate (20 mg), and pyrrolidine (20 μL) in 1,4-dioxane (1 mL) was stirred at 100° C. for 30 minutes using a microwave reaction apparatus.
Water was added to the reaction mixture, the solid matter was collected by filtration, and the obtained residue was purified by silica gel column chromatography (chloroform-methanol, NH silica), thereby obtaining 2-amino-5-(1-pyrrolidinyl)-1,3,4-thiadiazole (10 mg).
¹H-NMR (DMSO-d₆) δ: 6.27 (2H, s), 3.30-3.23 (4H, m), 1.93-1.88 (4H, m).

References:

US2015/322063,2015,A1 Location in patent:Paragraph 1125; 1126; 1127