5-Thiazolecarbonyl chloride, 2-chloro- (9CI) synthesis
- Product Name:5-Thiazolecarbonyl chloride, 2-chloro- (9CI)
- CAS Number:148637-74-5
- Molecular formula:C4HCl2NOS
- Molecular Weight:182.03
101012-12-8
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Yield:148637-74-5 100%
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 0 - 20;
Steps:
3 Example 3: The synthesis of compound (2)
[0099] At 0°C, oxalyl chloride (2.52 g, 0.02 mol) in dichloromethane (10 mL) is added dropwise into a suspension of2-chloro-thiazole-5-carboxylic acid (1.64 g, 0.01 mol) and N,N-dimethyl formamide (DMF) (1 drop) in dichloromethane(10 mL), and the mixture is stirred at room temperature overnight. The reaction mixture is evaporated under vacuum,and then the trace amount of oxalyl chloride is removed twice with additional dichloromethane (100 mL) azeotropicmixture to give compound (2-4) (1.82 g, 100%).
References:
EP2615092,2013,A1 Location in patent:Paragraph 0095; 0099
54045-76-0
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