![](/CAS/GIF/54237-09-1.gif)
5-Thiazolecarbonyl chloride, 4-methyl- (9CI) synthesis
- Product Name:5-Thiazolecarbonyl chloride, 4-methyl- (9CI)
- CAS Number:54237-09-1
- Molecular formula:C5H4ClNOS
- Molecular Weight:161.61
![4-Methylthiazole-5-carboxylic acid](/CAS/GIF/20485-41-0.gif)
20485-41-0
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$6.00/1g
![5-Thiazolecarbonyl chloride, 4-methyl- (9CI)](/CAS/GIF/54237-09-1.gif)
54237-09-1
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Yield:54237-09-1 99.2%
Reaction Conditions:
with N,N,N,N,N,N-hexamethylphosphoric triamide in toluene;
Steps:
15 EXAMPLE 15
EXAMPLE 15 In a similar apparatus to Example 1, 7.2 g (0.05 mole) of 4-methylthiazole-5-carboxylic acid were suspended in 100 ml of toluene, followed by the addition of 0.02 g of hexamethylphosphoramide Under heating and reflux, phosgene was blown at a rate of 1.2 l/hr for 2.5 hours (0.13 mole). After completion of the blowing, stirring was continued for additional 2 hours. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated to obtain 8.0 g of 4-methylthiazole-5-carboxylic acid chloride. Its purity and yield were 99.2% an d99.0%, respectively. NMR (δCDCl 3/TMS, ppm): 2.88(3H,s).
References:
US5136042,1992,A