ChemicalBook CAS DataBase List 5-(trifluoromethyl)-1,3-thiazole-4-carboxylic acid

5-(trifluoromethyl)-1,3-thiazole-4-carboxylic acid synthesis

1synthesis methods

Product Name:5-(trifluoromethyl)-1,3-thiazole-4-carboxylic acid
CAS Number:900530-68-9
Molecular formula:C5H2F3NO2S
Molecular Weight:197.14

ethyl 5-(trifluoromethyl)thiazole-4-carboxylate

900530-66-7
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5-(trifluoromethyl)-1,3-thiazole-4-carboxylic acid

900530-68-9
43 suppliers
$155.00/100mg

Yield: 93%

Reaction Conditions:

with water;sodium hydroxide in 1,4-dioxane at 20;

References:

Hodgetts, Kevin J.;Blum, Charles A.;Caldwell, Timothy;Bakthavatchalam, Rajagopal;Zheng, Xiaozhang;Capitosti, Scott;Krause, James E.;Cortright, Daniel;Crandall, Marci;Murphy, Beth Ann;Boyce, Susan;Brian Jones;Chenard, Bertrand L. [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 15,p. 4359 - 4363] Location in patent:experimental part