ChemicalBook CAS DataBase List 5-Trifluoromethyl-pyridin-3-ylamine

5-Trifluoromethyl-pyridin-3-ylamine synthesis

5synthesis methods

Product Name:5-Trifluoromethyl-pyridin-3-ylamine
CAS Number:112110-07-3
Molecular formula:C6H5F3N2
Molecular Weight:162.11

3-Pyridinamine, N-(diphenylmethylene)-5-(trifluoromethyl)-

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Yield: 90%

Reaction Conditions:

with hydrogenchloride in tetrahydrofuran;water at 20; for 2 h;

Steps:

2 Step 2: Synthesis of 5-(trifluoromethyl)pyridin-3-amine
Dissolve the imine obtained in Step 1 (850 mg, 2.6 mmol) in THF (10 mL), add water (2 mL), IN HCI solution (5 mL), stir the reaction at room temperature for 2 hrs. After the reaction, extract with EtOAc, wash the organic layer with saturated NaHC0₃ solution and brine sequentially, dry over anhydrous Na₂S0₄, and concentrate under reduced pressure to give the crude product. Purification by chromatography (silica gel, EtOAc:PE=l :l) affords the target compound (380 mg, 90%).

References:

CROWN BIOSCIENCE INC. (TAICANG);ZHANG, Deyi;ZHANG, Ruihao;ZHONG, Boyu;SHIH, Chuan WO2014/418, 2014, A1 Location in patent:Page/Page column 83

85148-26-1 Synthesis