ChemicalBook CAS DataBase List 2-Chloro-8-isopentyl-7-methyl-7,8-dihydropteridin-6(5H)-one

2-Chloro-8-isopentyl-7-methyl-7,8-dihydropteridin-6(5H)-one synthesis

5synthesis methods

Product Name:2-Chloro-8-isopentyl-7-methyl-7,8-dihydropteridin-6(5H)-one
CAS Number:501439-14-1
Molecular formula:C12H17ClN4O
Molecular Weight:268.74

Alanine, N-(2-chloro-5-nitro-4-pyrimidinyl)-N-(3-methylbutyl)-, methyl ester

1435462-61-5
0 suppliers
inquiry

2-Chloro-8-isopentyl-7-methyl-7,8-dihydropteridin-6(5H)-one

501439-14-1
31 suppliers
inquiry

Yield:501439-14-1 61%

Reaction Conditions:

Stage #1: methyl N-(2-chloro-5-nitropyrimidin-4-yl)-N-(3-methylbutyl)alaninatewith iron;acetic acid at 60; for 2 h;
Stage #2: with sodium hydrogencarbonate in water;ethyl acetate;

Steps:

1.c Step c: 2-Chloro-7-methyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5/-/)-one

A mixture of methyl /V-(2-chloro-5-nitropyrimidin-4-yl)-/V-(3-methylbutyl)alaninate (16.2 g, 49 mmol), iron powder (6.9 g, 123 mmol) and glacial acetic acid (165 mL) was heated at 60°C for 2 h. The reaction mixture was then filtered while hot over celite and washed with hot acetic acid (40 mL) followed by ethyl acetate (250 mL). The filtrate after evaporation was taken up in ethyl acetate and washed two times with aq. saturated sodium bicarbonate solution followed by brine. It was dried over sodium sulfate and evaporated. The residue was triturated with hot isopropyl ether to give titled product (yield: 61 %). ¹HNMR (300MHz, CDCI₃): δ 0.92-1 .01 (m, 7H), 1.43-1.75 (m, 5H), 3.01 -3.20 (m, 1 H), 4.10-4.25 (m, 2H), 7.63 (s, 1 H), 9.13 (s, 1 H).

References:

WO2013/71217,2013,A1 Location in patent:Page/Page column 30-32