2-(1-(Tert-Butoxycarbonyl)-4-Hydroxypiperidin-4-Yl)Acetic Acid synthesis
- Product Name:2-(1-(Tert-Butoxycarbonyl)-4-Hydroxypiperidin-4-Yl)Acetic Acid
- CAS Number:502482-52-2
- Molecular formula:C12H21NO5
- Molecular Weight:259.3
![tert-Butyl 4-[(ethoxycarbonyl)methyl]-4-hydroxypiperidine-1-carboxylate](/CAS/GIF/401811-97-0.gif)
401811-97-0
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502482-52-2
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Yield:502482-52-2 100%
Reaction Conditions:
Stage #1: 4-ethoxycarbonylmethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl esterwith water;sodium hydroxide in methanol; for 3 h;Reflux;
Stage #2: with hydrogenchloride in water; pH=4;
Steps:
12
00165] The material (730 mg) from the previous step was dissolved in the mixture of methanol (5 mL) and NaOH solution (10 N, 1 mL). The resulting mixture was refluxed for 3 hours and then cooled to room temperature. The solvent was evaporated, and the residue was re-dissolved in water and then extracted with diethyl ether. The aqueous solution was neutralized with cone. HC1 until pH = 4, and the aqueous layer was then extracted with dichloromethane. The combineddichloromethane layers were dried over NaS04. Evaporation of solvent gave 32 as white solid. 1H NMR (300 mHz ;CDC13) δ 1.44 (s, 9 H), 1.48 (m, 2 H), 1.66 (d, 2 H, J= 12.99 Hz), 2.46 (s, 2 H), 3.13 (t, 2 H, J = 11.7 Hz), 3.76 (b, 2 H).
References:
WO2011/32291,2011,A1 Location in patent:Page/Page column 52
79099-07-3
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502482-52-2
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41661-47-6
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502482-52-2
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24424-99-5
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502482-52-2
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