5-Amino-1-(4-chloro-phenyl)-1H-pyrazole-4-carboxylic acid amide synthesis
- Product Name:5-Amino-1-(4-chloro-phenyl)-1H-pyrazole-4-carboxylic acid amide
- CAS Number:50427-79-7
- Molecular formula:C10H9ClN4O
- Molecular Weight:236.66
51516-67-7
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Yield:50427-79-7 51%
Reaction Conditions:
with sulfuric acid at 0 - 20; for 1.5 h;
Steps:
3.2. General Procedure for the Synthesis of 5-Amino-1-aryl-1H-pyrazole-4-carboxamides 2a-j
General procedure: 2 mL of concentrated sulfuric acid (95-98%) was addedin a 10 mL round bottom flask in an ice bath (0°C) followedby slow addition, under stirring, of 0.001 mol of 5-amino-1-aryl-1H-pyrazole-4-carbonitrile 5a-j. The mixture was keptunder stirring for 90 min. The reaction was accompanied bymeans of TLC. Then, the reaction mixture was treated with asodium hydroxide solution (2 mol.L-1), until precipitation.The solid was filtered out and washed with cold water untilneutralized. After dry at room temperature, yellowish solidswere obtained.
References:
Ferreira, Byanca Silva;Silva, Rafaela Corrêa;Souto, Bernardo Araújo;Dos Santos, Maurício Silva [Letters in Organic Chemistry,2021,vol. 18,# 5,p. 335 - 343]
1073-70-7
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