2',3,4'-Trifluoro-[1,1'-biphenyl]-4-carboxylic acid synthesis

Yield:505082-86-0 85%

Reaction Conditions:

with Jones reagent in acetone at 0;

Steps:

30.2

Step 2: 3, 2', 4'-Trifluoro-biphenyl-4-carboxylic acid:To a cold solution of 3, 2', 4'-trifluoro-biphenyl-4-carboxaldehyde (0.45 g, 1.9 mmol) in acetone (10 ml_), the Jone's reagent was added slowly drop wise at 0⁰C until the reaction completes. Acetone was removed completely and the reaction mixture was diluted with water, extracted with ethyl acetateand the combined organic layers were washed with water and brine, dried over sodium sulphate and concentrated to get the title compound (0.410 g, 85%) 1H NMR (300 MHz, DMSOd₆): δ (ppm) = 7.2(m, 6H), 13.0(bs, 1 H).

References:

WO2010/115736,2010,A2 Location in patent:Page/Page column 92-93